A comprehensive overview of RET fusion lung caner’s characters, diagnosis and treatment
10.3760/cma.j.cn112434-20210219-00062
- VernacularTitle:RET融合肺癌的特征及诊疗进展
- Author:
Qianli MA
1
;
Jin ZHANG
;
Tong BAO
;
Junyi TIANZHOU
;
Chaoyang LIANG
;
Deruo LIU
Author Information
1. 中日友好医院胸外科，北京 100029
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2022;38(5):305-309
- CountryChina
- Language:Chinese
-
Abstract:
The RET(REarranged during transfection) gene as a novel has broken the therapeutic deadlock in the last two years, whith is attributed to the rapid approval of targeted therapies and inclusion in treatment guidelines, bringing more hope for the survival of patients with non-small cell lung cancer(NSCLC). Usually, the main activation of the RET proto-oncogene contributes to the development of lung cancer via somatic rearrangements. Thus, this study reviews the biological characteristics of RET gene, the classification of RET fusion in lung cancer and the detection of RET fusion. Meanwhile the pathological and clinical features, targeted therapies, drug resistance, prognosis of lung cancer patients with RET fusion were further discussed.
