Autophagy and bacterial infectious diseases.
10.3858/emm.2012.44.2.032
- Author:
Jae Min YUK
1
;
Tamotsu YOSHIMORI
;
Eun Kyeong JO
Author Information
1. Department of Microbiology, Chungnam National University School of Medicine, Daejeon 301-747, Korea. hayoungj@cnu.ac.kr
- Publication Type:Review ; Research Support, Non-U.S. Gov't
- Keywords:
autophagy;
cytokines;
immunity, Innate;
infection;
reactive oxygen species
- MeSH:
Animals;
Autophagy/*physiology;
Bacterial Infections/*immunology/metabolism;
Humans;
Immunity, Innate/physiology;
Reactive Oxygen Species/metabolism
- From:Experimental & Molecular Medicine
2012;44(2):99-108
- CountryRepublic of Korea
- Language:English
-
Abstract:
Autophagy is a housekeeping process that maintains cellular homeostasis through recycling of nutrients and degradation of damaged or aged cytoplasmic constituents. Over the past several years, accumulating evidence has suggested that autophagy can function as an intracellular innate defense pathway in response to infection with a variety of bacteria and viruses. Autophagy plays a role as a specialized immunologic effector and regulates innate immunity to exert antimicrobial defense mechanisms. Numerous bacterial pathogens have developed the ability to invade host cells or to subvert host autophagy to establish a persistent infection. In this review, we have summarized the recent advances in our understanding of the interaction between antibacterial autophagy (xenophagy) and different bacterial pathogens.
