Effects of L-menthol on suppression of gastric peristalsis during upper gastrointestinal endoscopy and the influencing factors
10.3760/cma.j.cn321463-20210615-00268
- VernacularTitle:L-薄荷醇制剂在上消化道内镜检查中抑制胃蠕动的有效性和影响因素研究
- Author:
Wenyan LI
1
;
Fandong MENG
;
Shutian ZHANG
;
Fachao ZHI
;
Zhaoshen LI
;
Zhanxiong XUE
;
Shuixiang HE
;
Weifeng CHEN
;
Yingxuan CHEN
;
Xiangbin XING
;
Chen YAO
;
Yongdong WU
Author Information
1. 首都医科大学附属北京友谊医院消化内科 国家消化系统疾病临床医学研究中心，北京 100050
- Keywords:
Gostroscopy;
Gastric peristalsis;
L-menthol
- From:
Chinese Journal of Digestive Endoscopy
2022;39(4):301-306
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects of single spay of L-menthol (NPO-11) on suppressing gastric peristalsis during upper gastrointestinal endoscopy and the influencing factor.Methods:This study was a multicenter, randomized, double-blind, placebo-parallel controlled study. The eligible patients were randomly divided into two groups by randomized blocks. Patients received local spray of either NPO-11 (160 mg L-menthol) or placebo 20 mL during upper gastrointestinal endoscopy. The gastric peristalsis was recorded and evaluated before, 2 minutes after and at the end of endoscopy. The complexity of the procedure was evaluated by the researchers. The influencing factors for antiperistaltic effect of NPO-11 were analyzed.Results:A total of 220 patients were enrolled from five research centers. There were 109 cases in the NPO-11 group and 111 cases in the placebo group. The baseline data of the two groups were similar and comparable. The proportion of patients with grade 1 peristalsis at 2 minutes after the treatment and at the end of endoscopy was significantly higher in the NPO-11 group than that in the placebo group [40.37% (44/109) VS 16.22% (18/111), χ2=15.93, P<0.001]. Compared with the placebo group, the proportions of weak peristalsis (grade 1 and 2) were higher in the NPO-11 group at 2 minutes after the treatment [67.89% (74/109) VS 46.85% (52/111)] and at the end of endoscopy [79.82% (87/109) VS 48.65% (54/111)]. Subgroup analysis showed that the inhibitory effect of NPO-11 on gastric peristalsis was more significant in Helicobacter pylori antibody positive group. Conclusion:Local spray of NPO-11 can effectively inhibit gastric peristalsis during upper gastrointestinal endoscopy, and its effect is more significant in Helicobacter pylori antibody positive group. It could be recommended for no obvious adverse reactions , its safety, and the convenient procedure.
