Efficacy of second session of endoscopic ultrasound-guided lauromacrogol ablation for pancreatic cystic neoplasms
10.3760/cma.j.cn321463-20211120-00692
- VernacularTitle:内镜超声引导下聚桂醇消融术治疗胰腺囊性肿瘤二次消融的疗效研究
- Author:
Chen DU
1
;
Ningli CHAI
;
Enqiang LINGHU
;
Huikai LI
;
Bo NING
;
Fei GAO
;
Xiuxue FENG
;
Ping TANG
Author Information
1. 解放军总医院第一医学中心消化内科医学部，北京 100853
- Keywords:
Pancreatic neoplasms;
Pancreatic cystic neoplasms;
Lauromacrogol;
Endoscopic ultrasound;
Second ablation
- From:
Chinese Journal of Digestive Endoscopy
2022;39(4):267-273
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of the second session of endoscopic ultrasound-guided lauromacrogol ablation (EUS-LA) for pancreatic cystic neoplasms (PCNs).Methods:A total of 74 patients with suspected of PCNs who underwent EUS-LA in the First Medical Center of Chinese PLA General Hospital from April 2015 to December 2020 were enrolled in the study. Fifteen of them underwent the second ablation. The efficiency of EUS-LA was determined based on the change of lesion volume during the imaging follow-up, categorized into complete resolution (CR), partial resolution (PR) and stable disease (SD). The safety was determined by the complication incidence.Results:Among the 15 patients undergoing the second EUS-LA, there were 9 males and 6 females with age of 51.5±17.6 years. Thirteen patients completed imaging follow-up after the second EUS-LA, CR was achieved in 8 patients, PR in 2 patients and 3 in SD. The CR rate increased from 0 after the first ablation to 8/13 after the second ablation ( P=0.002). The median cyst diameter decreased from 22.0 mm before the second ablation to 15.0 mm after the second ablation ( Z=-2.666, P=0.008) and the median cyst volume reduced from 2 419.7 mm 3 to 1 099.5 mm 3 ( Z=-2.134, P=0.033). The complication incidence of the second ablation was 2/15, similar to that of the first ablation. Conclusion:The second ablation is effective and safe without increasing the complication incidence in patients without achieving CR after the first EUS-LA.
