Short term effects of anti-reflux mucosectomy for proton pump inhibitor dependent gastroesophageal reflux disease
10.3760/cma.j.cn321463-20210823-00525
- VernacularTitle:内镜下抗反流黏膜切除术治疗质子泵依赖性胃食管反流病的短期疗效观察
- Author:
Nina ZHANG
1
;
Tian YANG
;
Ying LYU
;
Huimin GUO
;
Liangliang SHI
;
Fan ZHOU
;
Lei WANG
Author Information
1. 南京大学医学院附属鼓楼医院消化内科，南京 210008
- Keywords:
Gastroesophageal reflux;
Proton pump inhibitor dependent gastroesophageal reflux;
Anti-reflux mucosectomy
- From:
Chinese Journal of Digestive Endoscopy
2022;39(2):142-145
- CountryChina
- Language:Chinese
-
Abstract:
Clinical data of 26 patients with proton pump inhibitor dependent gastroesophageal reflux disease (GERD) who underwent anti-reflux mucosectomy (ARMS) in Nanjing Drum Tower Hospital from July 2017 to December 2020 were reviewed, and the GERD questionnaire (GERD-Q) score, the short-form reflux-qual (RQS) score, esophageal motility and 24 h esophageal pH parameters before and after ARMS were compared. With a median follow-up period of 18.4 months (6-27 months), 23 (88.5%) patients reported symptomatic improvement and 15 (57.7%) patients discontinued the use of proton pump inhibitors. After ARMS, the mean scores of GERD-Q (6.23 VS 13.19, P=0.004) and RQS (26.67 VS 10.98, P<0.001) were significantly improved, the mean DeMeester score (10.69 VS 53.15, P<0.001), the mean acid exposure time percentage (3.56% VS 9.92%, P<0.001) and the mean number of acid reflux episodes (36.9 VS 139.9, P=0.001) were lower, and the mean rest pressure at lower esophageal sphincter (LES) (25.19 mmHg VS 13.63 mmHg, P<0.001) and the mean distal contractile integral (1 819.15 mmHg·s·cm VS 1 007.67 mmHg·s·cm, P<0.001) were significantly increased compared with those before surgery. ARMS has significant short-term efficacy in the treatment of proton pump inhibitor dependent GERD, which can effectively improve reflux symptoms and life quality of patients, and strengthen the rest pressure of LES and peristalsis of the esophageal body.
