Efficacy of additional treatment after endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma
10.3760/cma.j.cn321463-20200320-00218
- VernacularTitle:浅表食管鳞状细胞癌内镜黏膜下剥离术后追加治疗的疗效分析
- Author:
Xiao LI
1
;
Lihua REN
;
Yu QIU
;
Chaohu YANG
;
Ruihua SHI
Author Information
1. 东南大学医学院，南京 210009
- Keywords:
Esophageal squamous cell carcinoma;
Submucosal infiltration;
Endoscopic submucosal dissection;
Additional therapy
- From:
Chinese Journal of Digestive Endoscopy
2022;39(2):118-122
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy of additional treatment (chemoradiotherapy or esophagectomy) after endoscopic submucosal dissection (ESD) for superficial esophageal squamous cell carcinoma.Methods:Clinicopathological data of 97 patients of esophageal squamous cell carcinoma with infiltration depth of M3-SM3 who underwent ESD in Zhongda Hospital from July 2014 to April 2019 were reviewed. There were 57 patients in the additional treatment group and 40 patients in the observation group. The rate of relapse-free survival (RFS) was evaluated by Kaplan-Meier method (used log-rank test).Results:In the additional treatment group, 15 underwent esophagectomy after ESD, and no tumor metastases were found, but 1 patient died of upper gastrointestinal bleeding after surgery; 42 underwent chemoradiotherapy, and all patients were alive, but 3 patients experienced distant metastases. In the observation group, 13 patients experienced local recurrence, 2 patients died of tumor recurrence and 1 patient died of cerebrovascular disorder. Kaplan-Meier analysis showed that the RFS rate of the additional treatment group was higher than that of the observation group ( P=0.001). Conclusion:ESD followed by additional chemoradiotherapy or esophagectomy has good clinical efficacy and can improve prognosis for superficial esophageal squamous cell carcinoma (M3-SM3) patients.
