Comparison of clinicopathological characteristics of main and accessory lesions in patients with synchronous multiple early esophageal cancer and intraepithelial neoplasia
10.3760/cma.j.cn321463-20200925-00687
- VernacularTitle:同时性多发早期食管癌和上皮内瘤变主病灶与副病灶临床病理特征的比较
- Author:
Shanshan XU
1
;
Ningli CHAI
;
Enqiang LINGHU
;
Shasha WANG
;
Xiuxue FENG
;
Bao LI
Author Information
1. 南开大学医学院，天津 300071
- Keywords:
Neoplasms, multiple primary;
Early esophageal cancer;
Intraepithelial neoplasia;
Synchronous;
Clinicopathological characteristics
- From:
Chinese Journal of Digestive Endoscopy
2021;38(12):1008-1012
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the clinicopathological characteristics of main and accessory lesions in patients with synchronous multiple esophageal lesions (SMEL, i. e. early esophageal cancer and intraepithelial neoplasia) and to explore their correlation.Methods:Data of 80 patients with SMEL treated by endoscopic resection in The First Medical Center of Chinese PLA General Hospital from November 2006 to September 2019 were retrospectively analyzed, and the clinicopathological characteristics as well. The lesions were divided into main and accessory lesions, and their correlation in macroscopic type, lesion location, pathological type and invasion depth in 70 patients with double SMEL were investigated.Results:The age of 80 patients with SMEL was 61.3±8.32 years, more common in males (83.8%, 67/80). Fifty-seven patients (71.2%) had a history of smoking and drinking, respectively. There was a positive correlation between the size of main and accessory lesions in the 70 patients with double SMEL ( r=0.464, P<0.001). The macroscopic type ( P=0.115), location ( P=0.340) and depth of invasion ( P=0.555) of the main and accessory lesions were not correlated, but the pathological type had high correlation ( P<0.001). The consistency rate was 50.0% (35/70). Conclusion:Most SMEL patients are elderly males with a history of smoking and drinking. When one lesion is found, there is high possibility of multiple lesions. Physicians should be aware of the correlation between main and accessory lesions to avoid missed diagnosis.
