Research progress in Neisseria gonorrhoeae lipooligosaccharides vaccine
10.3760/cma.j.cn112309-20211117-00388
- VernacularTitle:淋病奈瑟菌脂寡糖疫苗研究进展
- Author:
Xiangru YAN
1
;
Shiyang SUN
;
Shuxue SUN
;
Shumin ZHANG
;
Yinghua XU
;
Huanzhang XIA
Author Information
1. 沈阳药科大学生命科学与生物制药学院，沈阳 110000
- Keywords:
Neisseria gonorrhoeae;
Vaccine;
Lipooligosaccharides;
Immunogenicity;
Immune protection
- From:
Chinese Journal of Microbiology and Immunology
2022;42(5):415-419
- CountryChina
- Language:Chinese
-
Abstract:
Gonorrhea, caused by Neisseria gonorrhoeae, is one of the most frequently reported infectious diseases. With the increasing antibiotic resistance in Neisseria gonorrhoeae, gonorrhea has become a major public health problem worldwide, making it imperative to develop a safe and effective vaccine. Lipooligosaccharides (LOS), which exist on the outer surface of gram-negative bacteria, contain many important antigenic determinants. In recent years, a large number of studies have shown that LOS may become the most potential target of Neisseria gonorrhoeae vaccine and immunotherapy. This article reviewed the structure of LOS, its role in Neisseria gonorrhoeae infection, research progress in LOS vaccine and the challenges faced in vaccine development, aiming to provide reference for further study.
