Safety and immunogenicity of combined immunization with live rotavirus vaccine (oral) and measles, mumps and rubella vaccine
10.3760/cma.j.cn112309-20210926-00314
- VernacularTitle:口服轮状病毒活疫苗和麻疹-流行性腮腺炎-风疹联合减毒活疫苗同时免疫的安全性和免疫原性观察
- Author:
Xiaoqin LIU
1
;
Qi QI
;
Yu LIU
;
Yuan YANG
;
Min ZHANG
;
Haiping CHEN
;
Yanhui XIAO
;
Linyun LUO
Author Information
1. 中国生物技术股份有限公司营销中心，北京 100029
- Keywords:
Rotavirus vaccine;
Measles, mumps and rubella vaccine;
Safety;
Immunogenicity
- From:
Chinese Journal of Microbiology and Immunology
2022;42(4):317-322
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the difference in safety and immunogenicity of live rotavirus vaccine (oral) and measles, mumps and rubella (MMR) vaccine immunized alone or in combination.Methods:This study recruited 1 752 children aged 8-9 months who had not been vaccinated with live rotavirus vaccine (oral) or MMR vaccine after birth. The subjects were divided into three groups: study group (652 subjects, immunized with live rotavirus vaccine and MMR vaccine), control group 1 (723 subjects, immunized with live rotavirus vaccine) and control group 2 (377 subjects, immunized with MMR vaccine). Local and systemic adverse reactions within 30 d after vaccination were recorded. Serum samples were collected before and 35-42 d after immunization for analyzing the changes in antibodies.Results:Immunization alone or in combination with live rotavirus vaccine (oral) and MMR vaccine achieved similar results in the positive rates and concentrations of antibodies against rotavirus, measles and rubella viruses ( P>0.05). Moreover, the positive rates and the concentrations of the three antibodies were increased after vaccination. Compared with the control group 2, the concentration of antibody against mumps virus in the study group was increased ( P<0.05), but no significant difference in the positive rate of antibody against mumps virus was found between the two groups ( P>0.05). The positive rate and the concentration of antibody against mumps virus were increased after combined immunization or immunization with MMR vaccine alone. The overall incidence of fever and diarrhea was 1.54% (27/1 752) and 0.63% (11/1 752). No other abnormal reactions, incidental reactions or adverse reactions of any clinical significance were observed. Conclusions:Live rotavirus vaccine (oral) and MMR vaccine immunized alone or in combination showed good immunogenicity and safety.
