Role of eosinophil extracellular traps in the pathogenesis of chronic airway diseases
10.3760/cma.j.cn112309-20210602-00190
- VernacularTitle:嗜酸性粒细胞胞外诱捕网在慢性气道疾病发病机制中的作用
- Author:
Ping′an ZHANG
1
;
Yanliang MA
;
Xi CHEN
;
Yifan MA
;
Moqin ZHANG
Author Information
1. 北京大学人民医院呼吸与危重症医学科，北京 100044
- Keywords:
Eosinophil;
Extracellular traps;
Asthma;
Chronic obstructive pulmonary disease;
Allergic bronchopulmonary aspergillosis
- From:
Chinese Journal of Microbiology and Immunology
2022;42(3):241-244
- CountryChina
- Language:Chinese
-
Abstract:
Eosinophil extracellular traps (EETs), an important pathway of eosinophil to exert its effects, are composed of DNA fibers, histone and eosinophil granule proteins. Recently, many researches have shown that EETs play an important role in the genesis and development of respiratory diseases including asthma, allergic bronchopulmonary aspergillosis and chronic obstructive pulmonary disease. EETs can directly damage airway epithelial cells, promote airway inflammation and airway hypersecretion, increase the stickiness of secretions and induce the generation of autoantibody, helping eosinophils and their products participate in a cascade of events leading to inflammation and disease. Researches on EETs can also be helpful in investigating new targets for the treatment of chronic airway diseases.
