Role of Toll-like receptors in human papillomavirus infection-caused cervical cancer
10.3760/cma.j.cn112309-20210401-00106
- VernacularTitle:Toll样受体在人乳头瘤病毒感染致宫颈癌中的作用
- Author:
Chunlin ZHANG
1
;
Quan GONG
;
Bing MEI
Author Information
1. 长江大学附属荆州医院检验医学部，荆州 434020
- Keywords:
TLRs;
HPV;
Cervical cancer;
Single-nucleotide polymorphism;
Infection
- From:
Chinese Journal of Microbiology and Immunology
2022;42(1):73-77
- CountryChina
- Language:Chinese
-
Abstract:
Persistent infection with high-risk human papillomavirus (HR-HPV) is a well-defined etiology of cervical cancer, but not all HR-HPV infections lead to cervical cancer, indicating that many factors are involved in the regulation of HR-HPV pathogenicity. Toll-like receptors (TLRs) are a class of pattern recognition receptors that specifically recognize pathogen-associated molecular patterns (PAMPs) to provoke host innate and adaptive immunity against viruses. Relevant studies have shown that HR-HPV alters the local immune microenvironment by regulating the expression and signaling pathways of TLRs, leading to persistent infection with HR-HPV as well as cervical cancer. This review summarized and discussed the immune function and possible pathogenesis of TLRs in HPV infection-caused cervical cancer and the application of TLRs agonists in HPV vaccines.
