Immunoregulatory effects of leptin on inflammatory bowel disease

VernacularTitle:瘦素通过免疫调节对炎症性肠病的影响
Author: Jie CHEN ¹ ; Dandan LI ; Jianhua YI ; Tong′er LIANG
Author Information

1. 西南医科大学临床医学院，泸州　646000
Keywords: Inflammatory bowel disease; Leptin; Leptin blocker; Immunotherapy; Proinflammatory cytokine; Inflammatory signaling pathway
From: Chinese Journal of Microbiology and Immunology 2022;42(1):68-72
CountryChina
Language:Chinese
Abstract: Inflammatory bowel disease (IBD) is a chronic and recurrent disease characterized by chronic inflammation of the gastrointestinal tract. The quality of life of patients with IBD is seriously affected. The pathogenesis of IBD is complex, among which immune factors are considered to be the predominant factor. Leptin is a hormone derived from adipocytes and recent studies have shown that it is involved in the regulation of immune cells and inflammatory signaling pathways. This review summarized the pathogenesis of IBD, the immunoregulatory mechanism of leptin and research progress in immune modulators, introduced the potential effects of leptin on the regulation of immunological homeostasis in IBD and its potential roles in the etiology and pathogenesis of IBD, and discussed a possible immunotherapy method to treat IBD through leptin antagonist to reduce the inflammatory response and inhibit the inflammatory signaling pathways.