Variation of SARS-CoV-2 spike protein and its effects on neutralization sensitivity
10.3760/cma.j.cn112309-20220118-00019
- VernacularTitle:新型冠状病毒刺突蛋白的变异及其对中和活性的影响
- Author:
Jianhui NIE
1
;
Qianqian LI
;
Youchun WANG
Author Information
1. 中国食品药品检定研究院艾滋病性病病毒疫苗室，国家药品监督管理局生物制品质量研究与评价重点实验室，北京 102629
- Keywords:
SARS-CoV-2;
Spike protein;
Mutation;
Variant;
Antigenicity;
Neutralizing antibody
- From:
Chinese Journal of Microbiology and Immunology
2022;42(1):1-10
- CountryChina
- Language:Chinese
-
Abstract:
The COVID-19 epidemic that occurred at the end of 2019 spreads rapidly to all parts of the world, putting the global public health system to a severe test. With the continuation of the epidemic, SARS-CoV-2 variants are constantly emerging. In particular, the mutation of the spike protein can cause changes in the infectivity and antigenicity of the virus, resulting in an increase in the infectivity and a decline in the protective efficacy of existing vaccines, and even the replacement of epidemic strains. This is also one of the reasons why the epidemic has not been effectively controlled so far. Nowadays, the main circulating variants have changed their characteristics to a certain extent, and the neutralization sensitivity of some variants to neutralizing monoclonal antibodies, immune sera and convalescent sera has decreased to a certain extent compared with the original strains. The emergence of variants is not only related to the characteristics of the virus itself, but also to the changes of transmission host and the chronic infection in people with deficient immunity. The emerging variants should be closely monitored, and their functional characteristics should be systematically studied so as to provide data for vaccine research and development and the designation of immunization strategies.
