Trends in Helicobacter pylori resistance in Xiaoshan, Zhejiang: based on antibiotic resistance analysis of more than 50 000 strains
10.3760/cma.j.cn112309-20210811-00265
- VernacularTitle:浙江萧山地区幽门螺杆菌耐药趋势：基于5万余菌株抗生素耐药数据分析
- Author:
Juncai LIANG
1
;
Feng GUO
;
Li ZHONG
;
Lei ZHANG
;
Haixiang ZHANG
;
Qingqing TANG
Author Information
1. 温州医科大学附属萧山医院，杭州市萧山区第一人民医院消化内科 311200
- Keywords:
Helicobacter pylori;
Drug resistance;
Antibiotics
- From:
Chinese Journal of Microbiology and Immunology
2021;41(12):912-918
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze Helicobacter pylori ( Hp) resistance in Xiaoshan area from 2013 to 2020 and to provide reference for the selection of clinical antibiotics for the eradication of Hp in this area. Methods:Non-repetitive Hp strains isolated from patients treated in the First People′s Hospital of Xiaoshan District, Hangzhou from January 2013 to December 2020 and the drug susceptibility test results of these strains were collected. The patients were grouped by every 10 years of age to analyze the drug resistance of Hp in different groups and its changing trends. Results:A total of 54 912 Hp strains were isolated and cultured. The resistance rates of Hp isolates to amoxicillin, metronidazole, clarithromycin and levofloxacin were 0.42%, 92.94%, 22.41% and 29.83%, respectively. The drug resistance rates to clarithromycin and levofloxacin were increasing year by year. The resistance rates to levofloxacin, clarithromycin and metronidazole increased with age. The resistance rates to clarithromycin, levofloxacin and metronidazole in women were higher than those in men, especially in the 21-60 age group. The resistance rate to clarithromycin was significantly higher in people under 20 years old. In 2017 to 2019, the resistance rate to amoxicillin was higher in people under 20 years old than in other age groups. In 2020, the resistance rates to levofloxacin and clarithromycin in people over 70 years old both exceed 57% and increased rapidly. Conclusions:The resistance rates of Hp to levofloxacin, clarithromycin and metronidazole in Xiaoshan area were all at a high level. It was recommended to use individualized treatments for the eradication of Hp. In addition, attention should be paid to the young and older people.
