Intermittent theta burst stimulation can improve the spatially-delayed responses of working memory
10.3760/cma.j.issn.0254-1424.2022.05.001
- VernacularTitle:间歇性θ短阵脉冲刺激对工作记忆模型食蟹猴空间延迟反应的影响
- Author:
Lin ZHANG
1
;
Dongxu LIU
;
Yue LAN
;
Ge LI
;
Xiaolin LIU
;
Rui CHEN
;
Cheng WU
;
Zhong PEI
;
Guangqing XU
Author Information
1. 首都医科大学附属北京天坛医院康复医学科，北京 100070
- Keywords:
Working memory;
Spatial delayed response;
Cynomolgus macaques;
Magnetic stimulation;
Theta burst stimulation
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2022;44(5):385-389
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe any effect of intermittent theta burst stimulation (iTBS) on the spatially-delayed responses of working memory using cynomolgus macaques.Methods:The working memory of six male cynomolgus macaques (8-9 years old) was trained using a spatially-delayed response task. They were then randomly divided into an iTBS group and a control group, each of 3. The iTBS group was given iTBS at an intensity of 35% of the maximum output, with 2 seconds of stimulation followed by 8 seconds of rest with trains of 50Hz bursts repeated at a frequency of 5Hz over a period of 192 seconds once daily for 5 days, while the control group was given sham iTBS. Before and after the 5 days, the body weight and working memory of each animal were evaluated. The total number of effective feeding episodes, and of effective feeding episodes with short and long delay periods were recorded.Results:There was no significant change in the average body weight of either group before and after the modeling and iTBS intervention. After the intervention the number of total effective feeding cases and those with a short delay period were both significantly higher in the iTBS group than in the control group. However, no significant inter-group differences in the effective feeding cases with a long delay period were observed.Conclusions:iTBS is effective in improving the spatially-delayed responses of working memory, at least in cynomolgus macaques.
