Role of microRNA in complications of offspring born to mothers with gestational diabetes mellitus

VernacularTitle:微小RNA在妊娠期糖尿病子代并发症中的作用
Author: Shuyao HUANG ¹ ; Xia XU ; Jianying YAN
Author Information

1. 福建省妇幼保健院　福建医科大学附属医院产科，福州　350000
Keywords: Diabetes, gestational; Circulating microRNA; Prenatal exposure delayed effects; Pregnancy outcome
From: Chinese Journal of Perinatal Medicine 2022;25(3):233-236
CountryChina
Language:Chinese
Abstract: Gestational diabetes mellitus (GDM) can lead to adverse pregnancy outcomes and epigenetic changes in offspring due to exposure to a high-glucose intrauterine environment, resulting in related short- and long-term complications. MicroRNA (miRNA)-mediated post-transcriptional regulation, a gene expression regulation mechanism that has gained much attention in recent years, may play a role in morbidity in offspring born to mothers with GDM, such as macrosomia, heart development, neurodevelopment, and long-term metabolic diseases. This article reviews the progress of miRNA in GDM and associated complications in the offspring.