Prenatal diagnosis and pregnancy outcome of increased nuchal translucency with or without nuchal cystic hygroma in fetuses during first trimester
10.3760/cma.j.cn113903-20210305-00188
- VernacularTitle:早孕期颈项透明层增厚伴或不伴颈部淋巴水囊瘤胎儿的产前诊断结果及妊娠结局分析
- Author:
Kun DU
1
;
Fang FU
;
Xin YANG
;
Min PAN
;
Cuixing YI
;
Simin YUAN
;
Dongzhi LI
;
Can LIAO
Author Information
1. 广州市妇女儿童医疗中心优生围产研究所，广州 510623
- Keywords:
Nuchal translucency measurement;
Cystic hygroma;
Prenatal diagnosis;
Pregnancy outcome;
Pregnancy trimester, first
- From:
Chinese Journal of Perinatal Medicine
2022;25(2):104-109
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the prenatal diagnosis and pregnancy outcome of increased nuchal translucency (NT) with or without nuchal cystic hygroma (CH) in fetuses with first-trimester NT ≥5 mm.Methods:Data from 131 fetuses with NT ≥5 mm who received invasive prenatal diagnosis at Guangzhou Women and Children's Medical Center from July 2017 to December 2020 were retrospectively collected and analyzed. Those with a septum in the cyst were grouped as NT with CH group ( n=57), and those without as increased NT without CH group ( n=74). Genetic test results, incidence of structural malformations, survival rate after birth were compared using Chi-square test or Fisher's exact test and non-parametric test. Results:There was no significant difference in the incidence of fetal genetic abnormalities[67.6%(50/74) vs 61.4%(35/57), χ 2=0.54, P=0.464], ultrasonic structural malformations [21.6%(16/74) vs 33.3%(19/57), χ 2=2.26, P=0.133], or in the survival rate (12/14 vs 3/8, P=0.053) between increased NT without CH group and NT with CH group. Conclusions:For increased NT with or without CH, although the two groups had different spectrum of disease, they had a high incidence of chromosomal abnormalities and structural malformations, and both groups had a certain healthy survival rate after birth.
