Incidence of acute kidney injury following pancreaticoduodenectomy and related risk factors in elderly patients
10.3760/cma.j.cn441217-20210830-00016
- VernacularTitle:老年患者胰十二指肠切除术后急性肾损伤的发生率及其危险因素
- Author:
Wenwen ZHANG
1
;
Yue GU
;
Yajun HUANG
;
Mei GAO
;
Yingying REN
;
Yijia SHEN
;
Lei YAN
;
Fengmin SHAO
Author Information
1. 郑州大学人民医院（河南省人民医院）肾内科，郑州 450003
- Keywords:
Pancreaticoduodenectomy;
Aged;
Acute kidney injury;
Incidence;
Risk factors
- From:
Chinese Journal of Nephrology
2022;38(2):107-114
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the incidence of acute kidney injury (AKI) following pancreaticoduodenectomy and related risk factors in elderly patients.Methods:The clinical data of elderly patients who underwent pancreaticoduodenectomy in Henan Provincial People′s Hospital from January 2017 to June 2020 were collected retrospectively. According to the changes of serum creatinine within 48 h or 7 days after operation, the patients were divided into AKI group and non-AKI group. The basic clinical characteristics of the two groups were compared, and the incidence of AKI was calculated. Multivariate logistic regression model was used to analyze the risk factors of postoperative AKI.Results:A total of 322 elderly patients were enrolled, with age of (67.1±5.2) years old (60-85 years old) and 186 males (57.76%). Among 322 elderly patients, there were 41 patients (12.73%) suffering from AKI following pancreaticoduodenectomy. Compared with the non-AKI group, the level of bilirubin in AKI group was higher ( Z=-2.012, P=0.044), and the level of hemoglobin in AKI group was lower ( Z=-2.111, P=0.035). Multivariate logistic regression analysis showed that increased preoperative total bilirubin ( OR=1.003, 95% CI 1.000-1.006, P=0.027) and postoperative exploratory laparotomy ( OR=3.936, 95% CI 1.071-14.460, P=0.039) were the independent influencing factors for AKI after pancreaticoduodenectomy in elderly patients. Conclusions:The incidence of AKI after pancreaticoduodenectomy in elderly patients is 12.73%. Preoperative high bilirubin and postoperative exploratory laparotomy may be the independent risk factors for AKI after pancreaticoduodenectomy in elderly patients.
