Myelin-oligodendrocyte glycoprotein antibody-associated disease
10.3760/cma.j.cn113694-20220125-00055
- VernacularTitle:髓鞘少突胶质细胞糖蛋白抗体相关疾病
- Author:
Yangtai GUAN
1
;
Haojun YU
Author Information
1. 上海交通大学医学院附属仁济医院神经内科，上海 200127
- Keywords:
Myelin-oligodendrocyte glycoprotein;
Demyelinating autoimmune diseases;
Neuromyelitis optica
- From:
Chinese Journal of Neurology
2022;55(6):643-649
- CountryChina
- Language:Chinese
-
Abstract:
Myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently-established autoimmune central nervous system demyelinating disease, characterized by the detection of serum anti-myelin-oligodendrocyte glycoprotein antibody of IgG1 type. Sharing similar clinical manifestations with multiple sclerosis and aquaporin-4 antibody positive neuromyelitis optica spectrum disorder, it has yet demonstrated a unique disease course, pathological and radiological features. Therefore, MOGAD should be regarded as a disease entity to carry out further investigation. This review intends to summarize its pathogenesis, diagnosis and treatment progresses, so as to provide guidance for clinical practice.
