Research progress of therapeutic methods to restore dystrophin expression in Duchenne muscular dystrophy
10.3760/cma.j.cn113694-20210815-00559
- VernacularTitle:恢复杜氏肌营养不良症中抗肌萎缩蛋白表达的治疗方法研究进展
- Author:
Xuan WU
1
;
Liqiang YU
;
Meirong LIU
;
Qi FANG
Author Information
1. 苏州大学附属第一医院神经内科，苏州 215000
- Keywords:
Muscular dystrophy, Duchenne;
DMD gene;
Dystrophin;
Treatment
- From:
Chinese Journal of Neurology
2022;55(5):551-560
- CountryChina
- Language:Chinese
-
Abstract:
Duchenne muscular dystrophy (DMD) is a serious and progressive hereditary muscle disease. The DMD gene mutation on the X chromosome causes the loss of dystrophin, causing progressive muscle weakness and muscular atrophy. Most patients die for heart and lung failure. Current gene therapy methods are mainly aimed at restoring the expression of dystrophin, including read-through therapy, exon skipping therapy, vector-mediated gene replacement therapy and gene editing therapy. This article reviews the mechanisms of these different treatments and important advances in clinical research, and analyzes the challenges and application prospects of these treatments.
