Therapeutic effects and influencing factors of transcranial direct current stimulation on memory function in patients with Alzheimer′s disease

VernacularTitle:经颅直流电刺激对阿尔茨海默病患者记忆功能的治疗效果及影响因素
Author: Yang LIU ¹ ; Xuewei XIA ; Zhiqi MAO
Author Information

1. 桂林医学院附属医院神经外科，桂林　541000
Keywords: Alzheimer disease; Electric stimulation; Memory; Mechanism
From: Chinese Journal of Neurology 2022;55(5):529-536
CountryChina
Language:Chinese
Abstract: Alzheimer′s disease (AD) is a neurological disorder of unknown etiology characterized by memory loss and severe intellectual impairment. Transcranial direct current stimulation (tDCS) acts on the brains of AD patients in a non-invasive manner by reducing neurotoxic substances, promoting synaptic plasticity, producing long-term after-effects, weakening neuroinflammation, and reducing oxidative stress in brain tissue, among other mechanisms that affect patients′ memory functions. Therefore, tDCS has become an important tool to improve the memory of AD patients. And the effect of this treatment on memory improvement is influenced by factors such as stimulation site, current level, and stimulation duration.