The role and mechanism of intestinal microbiota metabolites in Alzheimer′s disease
10.3760/cma.j.cn113694-20220223-00132
- VernacularTitle:肠道菌群代谢物在阿尔茨海默病中的作用及机制
- Author:
Shaoling HUANG
1
;
Guoli SONG
Author Information
1. 深圳大学生命与海洋科学学院，深圳518060
- Keywords:
Alzheimer disease;
Lipopolysaccharides;
Bile acids and salts;
Amyloid;
Intestinal microbiota metabolites
- From:
Chinese Journal of Neurology
2022;55(5):524-528
- CountryChina
- Language:Chinese
-
Abstract:
The intestinal microbiota refers to the microbial group that exists in the intestine, and its composition disorder may affect human health. Many studies have found that intestinal microbiota and their metabolites may be closely related to the pathologies of Alzheimer′s disease (AD) through the gut-brain axis. This article will review the roles and possible mechanisms of lipopolysaccharide, functional bacterial amyloid proteins and bile acids, which are common metabolites of intestinal microbiota, in the pathogenesis of AD, and provide valuable information for exploring the pathogenesis of AD.
