The role of microglia in Alzheimer′s disease

VernacularTitle:小胶质细胞在阿尔茨海默病中的作用研究进展
Author: Xiangrong XIAO ¹ ; Ruolin LI ; Yanlei HAO
Author Information

1. 山东大学齐鲁医学院，济南　250012
Keywords: Alzheimer disease; Microglia; Inflammation; Biological markers
From: Chinese Journal of Neurology 2022;55(5):520-524
CountryChina
Language:Chinese
Abstract: At present, many drugs were developed based on the main pathological feature of Alzheimer′s disease (AD): "β-amyloid cascade hypothesis and abnormal tau protein aggregation" as targets, but the efficacy is unsatisfactory. With the progress on the study of pathological mechanism of AD, the role of microglia and their related expression genes, such as TREM2, CD 33, ABCA7 gene and their related signal transduction pathways in the pathological mechanism of AD has been paid more and more attention. The study on AD biomarkers and therapeutic targets based on microglia and their related expression genes has also increased significantly. This review will mainly focus on the pathophysiology of microglia, the mechanism of microglia in AD, the biomarkers related to microglia and the drug treatment of AD.