A case of limbic encephalitis with positive anti-leucine-rich glioma inactivated 1 protein antibody and anti-myelin oligodendrocyte glycoprotein antibody
10.3760/cma.j.cn113694-20210909-00623
- VernacularTitle:抗富亮氨酸胶质瘤失活1蛋白和抗髓鞘少突胶质细胞糖蛋白双抗体阳性的边缘叶脑炎1例
- Author:
Xiaojiao DONG
1
;
Haoxiang YANG
;
Liyong YIN
;
Hongli LIU
Author Information
1. 秦皇岛市第一医院神经内科，秦皇岛 066000
- Keywords:
Limbic encephalitis;
Leucine-rich glioma inactivation 1 protein antibody;
Myelin oligodendrocyte glycoprotein antibody
- From:
Chinese Journal of Neurology
2022;55(5):501-506
- CountryChina
- Language:Chinese
-
Abstract:
A case of limbic encephalitis with positive anti-leucine-rich glioma inactivated 1 protein (LGI1) antibody and anti-myelin oligodendrocyte glycoprotein (MOG) antibody was reported. The patient was a middle-aged male with a history of retinal vein occlusion. The main symptoms were temporal lobe epilepsy, facial arm dystonia, autonomic nerve dysfunction. Magnetic resonance imaging showed long T 2 signal in the right hippocampus without enhancement and normal perfusion. Electroencephalogram showed paroxysmal slow wave and sharp slow wave in interictal period. Blood anti-MOG antibody, blood and cerebrospinal fluid anti-LGI1 antibody were double positive. The main diagnosis was limbic encephalitis. After treatment with hormone and gamma globulin, the symptoms were improved and double antibodies were turned negative. Anti-LGI1/MOG double positive cases are rare, and the clinical manifestations and imaging manifestations of double positive antibody cases are not completely consistent with those with each single antibody, with different characteristics. This report can help clinicians enhance awareness.
