Anti-neurexin-3α antibody-associated encephalitis with parkinsonism as the main manifestation: a case report
10.3760/cma.j.cn113694-20211219-00899
- VernacularTitle:以帕金森症状为主要表现的抗突触蛋白-3α抗体相关脑炎1例
- Author:
Heqing ZHENG
1
;
Lanxiang WU
;
Sheng TIAN
;
Pan LIU
;
Mingxu LIU
;
Wei WU
Author Information
1. 南昌大学第二附属医院神经内科，南昌330006
- Keywords:
Autoimmune diseases of the nervous system;
Synapsins;
Parkinsonian disorders;
Antibodies
- From:
Chinese Journal of Neurology
2022;55(5):497-500
- CountryChina
- Language:Chinese
-
Abstract:
Anti-neurexin-3α antibody-associated encephalitis is rare in clinical practice. It often has a history of pre-infection. It is characterized by abnormal mental behavior, seizures, decreased consciousness, cognitive and sleep disorders, movement disorder, central hypoventilation and autonomic nervous dysfunction. Among them, dyskinesias are mainly involuntary movements of the mouth, face and limbs, dystonia, myoclonic seizures and other manifestations of increased movement. Parkinson′s symptoms manifested as decreased movement are rarely reported. A encephalitis patient with positive anti-neurexin-3α antibody is reported, who is a young female, mainly with parkinsonism such as slow movement, unsteady walking, difficulty in starting and turning around, and inability to hold things in both upper limbs, accompanied by abnormal mental behavior and cognitive dysfunction. After treatment with methylprednisolone and intravenous immunoglobulin, the prognosis is good.
