Analysis of a case of corticobasal degeneration started with primary progressive aphasia
10.3760/cma.j.cn113694-20210714-00493
- VernacularTitle:以原发性进行性失语起病的皮质基底节变性1例分析
- Author:
Sen HUANG
1
;
Jianing LIN
;
Pian HUANG
;
Weineng CHEN
;
Minying ZHENG
;
Xiaoli YAO
Author Information
1. 中山大学附属第一医院神经科 广东省重大神经疾病诊治研究重点实验室 国家临床重点专科和国家重点学科，广州510080
- Keywords:
Basal ganglia;
Nerve degeneration;
Aphasia, primary progressive;
Movement disorders;
Clinical features
- From:
Chinese Journal of Neurology
2022;55(4):336-340
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Through a typical case of corticobasal degeneration (CBD) with primary progressive aphasia (PPA) to analyze the clinical characteristics of CBD and the special manifestations of aphasia with that disease.Methods:Retrospective analysis was performed on a patient with PPA based CBD who was admitted to the First Affiliated Hospital, Sun Yat-sen University in July 2020 to summarize the clinical features and diagnostic thinking of CBD.Results:The patient was a 59-year-old male, manifested rapidly progressive dysfunction of language and memory function. The aphasia was mainly featured as slow speech, reduced content and grammatical errors, and diagnosed as PPA, non-fluent grammatical variation. The imaging results showed the atrophy of the left frontal lobe, parietal lobe, basal ganglia and thalamus, coupled with the reduction in 18F-fluorodeoxyglucose radioactive uptake. The patient was finally diagnosed as possible CBD. Conclusions:PPA as the initial manifestation of CBD is very rare in clinical practice. The high non-specificity of clinical features and the lack of typical motor symptoms result in the difficulty of correct diagnosis of CBD. Timely functional imaging in nuclear medicine and reliable biomarkers help to facilitate early diagnosis of atypical CBD.
