Progress in cerebral venous collagenosis
10.3760/cma.j.cn113694-20210625-00441
- VernacularTitle:脑静脉胶原病的研究进展
- Author:
Yuan CAO
1
;
Yicheng ZHU
Author Information
1. 中国医学科学院北京协和医院神经科，北京100730
- Keywords:
Cerebral venous collagenosis;
Cerebral small vessel disease;
Alzheimer disease;
Pathological features;
Pathogenesis
- From:
Chinese Journal of Neurology
2022;55(2):169-174
- CountryChina
- Language:Chinese
-
Abstract:
Moody and colleagues discovered the presence of venous collagenosis (VC) in periventricular of human brains by pathological study obtained at autopsy in 1995, which was described as a noninflammatory collagenous thickening of venous walls resulting in severe periventricular venous stenosis or occlusion. Due to the lack of specific markers and staining methods, there are few studies of cerebral venous disease, and the pathological features and pathogenesis are still unclear. However, studies have reported that VC is associated with cerebral small vessel disease (CSVD) and Alzheimer′s disease (AD), suggesting that VC may play an important role in exploring and elucidating pathogenesis. The article aims to provide a review of researches on VC pathological features, possible pathogenesis and correlation with CSVD and AD.
