Clinical manifestations of pulmonary cryptococcosis: an analysis of 113 cases
10.3760/cma.j.cn114798-20210629-00503
- VernacularTitle:肺隐球菌病113例临床分析
- Author:
Xiaoyu LU
1
;
Zhangchu JIN
;
Fugui YAN
;
Wen LI
;
Huahao SHEN
Author Information
1. 浙江大学医学院附属第二医院呼吸与危重症医学科 浙江省呼吸疾病诊治及研究重点实验室，杭州 310009
- Keywords:
Mycoses;
Cryptococcosis;
Diagnosis
- From:
Chinese Journal of General Practitioners
2022;21(2):128-134
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analysis of clinical and imaging characteristics of pulmonary cryptococcosis.Methods:The clinical and imaging characteristics of 113 patients with pulmonary cryptococcosis who were admitted to the Second Affiliated Hospital of Zhejiang University School of Medicine from January 2014 to March 2019, were retrospectively analyzed.Results:Among 113 patients, 74 cases (65.5%) were males, and 71 cases (62.8%) were at a age of 40-60 years. The imaging manifestations showed a nodular-infiltrating patchy mixed type ( n=44,38.9%), accompanied by halo sign ( n=48, 42.5%) and bronchial air sign ( n=48, 42.5%). All patients were treated with fluconazole and the follow-up at 3 months after discharge showed their conditions were all improved. Subgroup analysis showed that patients with complications had older average age [(54.28±10.64)y vs. (46.52±12.12)y, t=-5.05, P<0.001], longer hospital stay [(10.42±6.11)d vs. (7.09±5.63)d, t=-4.28, P=0.007], lower white blood cell count [(6.02±2.16)×10 9/L vs. (6.96±2.29)×10 9/L, t=2.44, P=0.027]. The symptomatic group had fewer male patients [56.2% (45/80) vs. 87.9% (29/33), χ 2=19.54, P<0.001], and imaging was more likely to show infiltrative patchy [32.5%(26/80) vs. 9.1%(3/33), χ 2=18.25, P=0.031]. There was no significant difference in clinical and imaging manifestations between antigen positive group and antigen negative group(all P>0.05). Conclusions:Most of the patients with pulmonary cryptococcosis are middle-aged men, and have nodular-infiltrating patchy mixed type in imaging; the complications would prolong the length of hospital stay.
