Clinical efficacy of kidney transplantation from senile living-related donors aged over 70 years: a report of 18 cases
10.3760/cma.j.cn421203-20211116-00282
- VernacularTitle:70岁以上老年供肾活体肾移植18例疗效分析
- Author:
Hongtao LIU
1
;
Lexi ZHANG
;
Guozheng PAN
;
Shihui LI
;
Jianfeng YE
;
Cheng QIU
;
Daqing PAN
;
Shuai DAI
Author Information
1. 中国科学技术大学附属第一医院（安徽省立医院）肾移植科，合肥 230036
- Keywords:
Kidney transplantation;
Olderly donated kidney;
Living kidney transplantation
- From:
Chinese Journal of Organ Transplantation
2022;43(3):146-150
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical efficacy of kidney transplantation(KT)from senile living-related donors aged over 70 years.Methods:Between 2017 and 2019, perioperative and follow-up data from 18 pairs of donors and recipients were retrospectively reviewed.Results:Operations of all 18 pairs of recipients and donors were conducted successfully without serious perioperative complications.No delayed graft function occurred.There was 1 episode(5.6%)of acute rejection.The mean level of serum creatinine(SCr)at Day 3 post-KT and at discharge was(155.7±63.5)and(97.6±28.7)μmol/L.The median follow-up period was 37.5 months.All 18 donors survived with normal renal function.And no proteinuria or kidney donation related hospitalization events occurred.SCr was(84.4±15.0)μmol/L at the last follow-up and there was no statistical significance as compared with SCr level at discharge( P=0.610). No recipient mortality or graft loss occurred.Levels of SCr were(92.1±18.3), (95.5±21.9)and(100.1±21.2)μmol/L at Month 12/24 and the last follow-up.No statistical difference existed in posttransplant SCr level at these follow-up timepoints( P=0.507). Posttransplant proteinuria occurred in 3 recipients(16.7%). In 8 donors, donated kidney glomerular filtration rate(GFR)was lower than 40 ml/(min·1.73m 2). No statistical difference existed in posttransplant SCr level between this group and higher GFR group( P>0.05). Conclusions:After thorough preoperative assessments, satisfactory short-term outcomes may be achieved for KT from living-related donors aged over 70 years.The long-term outcome should be further explored.
