Analysis of treatment strategies for donor-derived infection: a report of 486 cases
10.3760/cma.j.cn421203-20210224-00067
- VernacularTitle:486例供者来源感染病原体分析
- Author:
Shengli CAO
1
;
Xiaoyi SHI
;
Peihao WEN
;
Jianle HAN
;
Changan WANG
;
Wenzhi GUO
;
Shuijun ZHANG
Author Information
1. 郑州大学第一附属医院肝胆胰外科 河南省消化器官移植重点实验室 河南省器官移植工程技术研究中心 河南省高等学校肝胆胰外科与消化器官移植重点学科开放实验室，郑州 450052
- Keywords:
Liver transplantation;
Donor;
Infection
- From:
Chinese Journal of Organ Transplantation
2022;43(3):135-140
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the microbiological characteristics of donor blood culture and donor liver perfusion culture and summarize the clinical experiences to provide basic rationales for preventing donor-derived infections.Methods:From August 1, 2018 to November 26, 2018 and November 27, 2018 to December 31, 2020 at First Affiliated Hospital, Zhengzhou University, culture results of donor blood and donor liver perfusate were retrospectively reviewed.According to whether or not donor liver was obtained without breaking diaphragm, removing gallbladder intraoperatively and flushing bile through cystic duct, two stages were assigned: before and after improvement measures of liver donor, i.e.August 1, 2018 to November 26, 2018 and November 27, 2018 to December 31, 2020.The culture results of donor blood samples and donor liver perfusion fluid samples in two stages of liver transplantation were statistically analyzed and infection preventing measures during donor liver maintenance and obtaining donor liver examined.Results:A total of 486 cases of blood culture from potential donors and 478 cases of liver perfusion culture were analyzed.The results showed that the incidence of blood culture infection was 4.5% and 4.3% before and after improvement measures( χ2=0.008; P=0.927)while the incidence of perfusion fluid infection was 56.8% and 46.2%( χ2=4.569; P=0.031); Klebsiella pneumoniae was a major pathogen cultured in perfusion solution before improvement measures and Staphylococcus epidermidis after improvement measures. Conclusions:Before organ donation, infection screening and prevention of potential donors and corresponding measures during donor liver acquisition can reduce donor source infection and effectively lower the mortality of recipients.
