Analysis of gonad and reproductive function of recipients after hematopoietic stem cell transplantation in severe aplastic anemia
10.3760/cma.j.cn421203-20210530-00160
- VernacularTitle:重型再生障碍性贫血造血干细胞移植后受者性腺及生育功能分析
- Author:
Yafang GUO
1
;
Liangming MA
;
Qiujuan ZHU
;
Rong GONG
;
Zhilin GAO
;
Weiwei TIAN
;
Tao WANG
Author Information
1. 山西白求恩医院 山西医科大学第三医院血液内科，太原 030032
- Keywords:
Hematopoietic stem cell transplantation;
Aplastic anemia;
Receiver pretreatment;
Fertility
- From:
Chinese Journal of Organ Transplantation
2021;42(12):744-749
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the effects of two pretreatment schemes on the efficacy, gonad and reproductive function of haploid hematopoietic stem cell transplantation recipients with severe aplastic anemia(SAA).Methods:The data of 73 patients with SAA who underwent haploid hematopoietic stem cell transplantation were analyzed retrospectively.The pretreatment scheme was divided into Fludarabine+ Cyclophosphamide+ Antithymocyte globulin group(FC lowATG group, 45 cases)and Busulfan+ Cyclophosphamide+ Antithymocyte globulin group(Bucy/ATG group, 28 cases). The changes of blood cell implantation time, follicle stimulating hormone(FSH), luteinizing hormone (LH), estradiol and testosterone were compared between the two groups. Results:there was no significant difference in blood cell implantation time between the two groups( P=0.096; P=0.133). The levels of FSH and LH in female recipients in Bucy/ATG group were higher than those in FC lowATG group, and the level of estradiol was lower than that in FC lowATG group.There were significant differences between the groups(all P<0.05). The pregnancy or fertility rate of female recipients in Bucy/ATG group was lower than that in FC lowATG group(all P<0.05). There was no significant difference in FSH, LH, testosterone and fertility between the two groups(all P>0.05). There was no significant difference in 2-year overall survival rate and failure free survival rate between the two groups( P=0.091; P=0.084). Conclusions:FC lowATG may be an effective pretreatment scheme for haploid hematopoietic stem cell transplantation in SAA with less damage to gonad and reproductive function.
