Expressions and clinical significance of plasma exosomal hsa_circ_0022417 in gastric cancer
10.3760/cma.j.cn113855-20210818-00496
- VernacularTitle:胃癌患者血浆外泌体hsa_circ_0022417的表达及其临床意义
- Author:
Huijie GAO
1
;
Wei GUO
;
Xuanhu XIE
;
Peipei LU
;
Peiming ZHENG
Author Information
1. 河南大学第一附属医院肿瘤科，开封 475000
- Keywords:
Stomach neoplasms;
Diagnosis;
Exosome;
CircRNA
- From:
Chinese Journal of General Surgery
2022;37(4):275-278
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate expressions and clinical significance of plasma exosomal hsa_circ_0022417 in gastric cancer (GC).Methods:Sixty gastric cancer patients, 30 chronic gastritis patients (disease control group) and 30 healthy volunteers (healthy control group) were enrolled in this study. The expression levels of plasma exosomal hsa_circ_0022417 and serum CEA and CA19-9 were detected. The ROC curve and AUC were used to estimate the diagnostic capacity.Results:Compared with chronic gastritis patients and healthy control, the expression of plasma exosomal hsa_circ_0022417 was significantly upregulated in the gastric cancer group ( F=9.96, P<0.05). The expression level of hsa_circ_0022417 in GC tissue was significantly higher than that in adjacent tissue ( t=6.08, P<0.05). The AUC of hsa_circ_0022417, serum CEA and CA 19-9 was 0.79, 0.68 and 0.66, respectively. The combined detection of three indicators had the highest AUC (0.86) ( P<0.05). The expression level of exosomal hsa_circ_0022417 was significantly correlated with tumor size ( χ2=6.42, P<0.01), differentiation degree ( χ2=5.83, P=0.05), TNM stage ( χ2=7.14, P<0.05) and lymph node metastasis ( χ2=5.17, P<0.05). Conclusion:Exosome hsa_circ_0022417 is highly expressed in the plasma of GC patients, which is of great significance for clinical auxiliary diagnosis and early screening of GC.
