Effect of albumin to fibrinogen ratio on the prognosis of patients undergoing radical resection for colorectal cancer
10.3760/cma.j.cn113855-20210726-00458
- VernacularTitle:白蛋白与纤维蛋白原的比值对结直肠癌根治术患者预后的预测价值
- Author:
Honggang WANG
1
;
Haoran HU
;
Yong XIA
;
Yaxing ZHOU
;
Long YANG
;
Lijun LI
;
Yong WANG
;
Jianguo JIANG
;
Qinghong LIU
Author Information
1. 泰州市人民医院普通外科，泰州 225300
- Keywords:
Colorectal neoplasms;
Albumin;
Fibrinogen;
Prognosis
- From:
Chinese Journal of General Surgery
2022;37(4):241-244
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of albumin to fibrinogen ratio on the prognosis of patients undergoing radical resection for colorectal cancer.Methods:Clinical and pathological data of 216 patients who underwent laparoscopic radical resection of colorectal cancer at the General Surgery Department of Taizhou People's Hospital from Aug 2015 to Jul 2017 were retrospectively analyzed. Albumin and fibrinogen results within 7 days before surgery was collected. The optimal cut-off point of AFR was determined by Youden index of ROC curve. Kaplan-Meier analysis, univariate and multivariate COX regression models were used to analyze the prognostic factors of OS and DFS.Results:The best postoperative OS threshold of AFR for patients undergoing laparoscopic radical resection of colorectal cancer was 9.43. Univariate analysis and multivariate COX regression analysis showed that age ≤65 years, TNM stage Ⅰ-Ⅱ, and AFR≥9.43 had better OS and DFS (all P<0.05). Conclusions:Preoperative AFR level had a good predictive value on postoperative survival of patients undergoing laparoscopic radical resection of colorectal cancer, and AFR<9.43 was an independent risk factor for postoperative OS and DFS.
