The correlation between cardiac troponinⅠ level and short-term mortality after liver transplantation
10.3760/cma.j.cn113855-20210317-00171
- VernacularTitle:肝移植术后心肌肌钙蛋白Ⅰ水平与短期死亡风险的相关性分析
- Author:
Shuyan GUO
1
;
Jingyi WANG
;
Xi ZHENG
;
Huimiao JIA
;
Yijia JIANG
;
Yibing WENG
;
Wenxiong LI
Author Information
1. 首都医科大学附属北京潞河医院重症医学科，北京 101100
- Keywords:
Troponin Ⅰ;
Liver transplantation;
Prognostic factors
- From:
Chinese Journal of General Surgery
2022;37(3):207-211
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the correlation between elevated cTnI level and 28-day mortality after liver transplantation.Methods:A retrospective study was conducted in adult patients admitted to ICU after liver transplantation from Jun 2015 to March 2019 at Beijing Chao-Yang Hospital. The cardiac troponin Ⅰ levels within 48 h after surgery were examined. Patients outcome was followed up,the primary end point was mortality within 28-day. Univariate and multivariate logistic regression models were used to look for predictors of 28-day mortality.Results:Three hundred and eighteen patients were included in our analyses. Twenty-six patients died and 292 survived within 28 days after LT. Two hundred and forty-three of 318 (76.4%) cases presented elevated cTnI in the early stage after LT. Thirty-seven of 318 (11.6%) patients presented a moderate elevation of cTnI level (5-10 times over normal upper limit), 75 (23.6%) of them presented severe cTnI elevation (10 times over normal upper limit). Univariate and multivariate logistic regression model shows severe cTnI elevation was the independent prognostic factors associated with 28-day mortality [Odds Ratio (95% confidence interval)=3.151(1.218-8.150), P=0.018]. Conclusion:Early cTnI elevation is common after liver transplantation, and severe cTnI elevation is significantly associated with 28-day mortality.
