Application of high-dose intravenous immunoglobulin in the treatment of severe dermatoses
- VernacularTitle:大剂量静脉注射免疫球蛋白在重症皮肤病治疗中的应用进展
- Author:
Danqi LI
1
;
Yuchen LOU
;
Juan TAO
Author Information
- Keywords: Immunoglobulins, intravenous; Skin diseases; Severe dermatoses
- From: Chinese Journal of Dermatology 2022;55(5):455-459
- CountryChina
- Language:Chinese
- Abstract: High-dose intravenous immunoglobulin (IVIG) has emerged as an effective treatment option for some refractory and severe dermatoses with few adverse reactions. The Fab and Fc fragments of IgG can exert anti-inflammatory effect by mediating specific downstream reactions via binding to a variety of autoantigens, autoantibodies and complements. This review summarizes action mechanisms of IVIG, focuses on the progress towards its application in severe dermatoses (such as severe drug eruption, refractory dermatomyositis and autoimmune bullous diseases) and special populations, as well as its adverse reactions.
