Role of mast cells in the pathogenesis of allergic contact dermatitis
10.35541/cjd.20200110
- VernacularTitle:肥大细胞在变应性接触性皮炎发病中的作用进展
- Author:
Xiaoli SUN
1
;
Linfeng LI
Author Information
1. 北京怀柔医院皮肤科，北京 101400
- Keywords:
Dermatitis, allergic contact;
Mast cells;
Allergens;
Sensitization
- From:
Chinese Journal of Dermatology
2022;55(5):449-451
- CountryChina
- Language:Chinese
-
Abstract:
Allergic contact dermatitis (ACD) is a T cell-mediated inflammatory skin disease induced by contact allergens. The role of mast cells in ACD remains controversial. In the sensitization phase, mast cells play a pro-inflammatory role by releasing inflammatory cytokines to promote recruitment of neutrophils, and affect the sensitization process by stimulating or inhibiting the migration of dendritic cells. During the elicitation phase, mast cells promote non-allergen-specific inflammation, and enhance allergen-specific inflammation in moderate ACD, but inhibit allergen-specific inflammation in severe and chronic ACD. In addition to the IgE-Fcε receptor I-histamine pathway, Mas-related G-protein coupled receptor B2/X2 (MrgprB2/X2) can mediate the activation of mast cells, leading to the release of tryptase to drive non-histaminergic itch, and may serve as a new target for the treatment of ACD.
