Transcriptomics in atopic dermatitis
- VernacularTitle:特应性皮炎的转录组学研究进展
- Author:
Shichun QIN
1
;
Mengjie LI
;
Xiaoyun LU
;
Fengli XIAO
Author Information
- Keywords: Atopic dermatitis; Transcriptome; Microchip analytical procedures; RNA sequencing
- From: Chinese Journal of Dermatology 2022;55(4):365-369
- CountryChina
- Language:Chinese
- Abstract: With the development of transcriptomic technologies such as gene chip technology and RNA sequencing technology, important related factors in the pathogenesis of atopic dermatitis (AD) have been gradually identified, such as different T helper (Th) cell subtypes and other immune-related cells (macrophages and Langerhans cells) ; abnormal changes in active substances such as interleukin-4, interleukin-13, fillagrin and loricrin released by immune-related cells such as Th2 cells and keratinocytes have been found to play major roles in pruritus and skin barrier damage in AD. In recent years, transcriptomic technologies have been applied to the analysis of changes in transcriptomic profiles of patients before and after treatment to evaluate patients′ condition and therapeutic effect. This review summarizes research progress in transcriptomics in AD in recent years.
