PI3K/Akt/mTOR signaling pathway in cutaneous squamous cell carcinoma
- VernacularTitle:PI3K/Akt/mTOR信号通路在皮肤鳞状细胞癌中的研究进展
- Author:
Congcong XU
1
;
Hao CHEN
Author Information
- Keywords: Neoplasms, squamous cell; Signal transduction; Skin; PI3K/Akt/mTOR
- From: Chinese Journal of Dermatology 2022;55(3):264-267
- CountryChina
- Language:Chinese
- Abstract: The pathogenesis of cutaneous squamous cell carcinoma (cSCC) is complicated, and treatment methods of advanced cSCC remain insufficient. This review summarizes the role of phosphatidylinositol 3-kinase (PI3K) /protein kinase B (Akt) /mammalian target of rapamycin (mTOR) signaling pathway in the pathogenesis of cSCC, as well as progress in the treatment of cSCC targeting this pathway, and provides new ideas for targeted therapy of cSCC.
