The 496th case:recurrent syncope for 8 years
10.3760/cma.j.cn112138-20210607-00403
- VernacularTitle:临床病例讨论 第496例——反复晕厥8年
- Author:
Weiting TANG
1
;
Yong YOU
;
Shuangxing LI
;
Bin ZHANG
Author Information
1. 海南医学院第二附属医院神经内科，海口 570216
- Keywords:
Syncope;
Postural tachycardia syndrome;
Joint hypermobility;
Ehlers-Danlos syndrome
- From:
Chinese Journal of Internal Medicine
2022;61(6):708-710
- CountryChina
- Language:Chinese
-
Abstract:
A 25-year-old women was admitted to the department of Neurology in Affiliated 2nd Hospital of Hainan Medical University due to recurrent syncope for 8 years and return for 2 months. She had multiple episodes of syncope at onset. She presented with the feeling of weakness in both lower limbs, and fatigue in the past year. She experienced pain in the waist and limbs joint in recent three months. Physical examination showed joint hyperactivity in metacarpophalangeal joints of both upper limbs, increased skin elasticity. Active-standing transcranial Doppler (TCD) test showed that the average heart rate (HR) and the average middle cerebral artery (MCA) blood flow velocity in the supine position were 79 beats/min and 62 cm/s, respectively; while the average HR and the average MCA blood flow velocity in the standing position were 126 beats/min, 47 cm/s. Meanwhile,the blood pressure was normal during the test of supine-to-standing TCD. Genetic testing indicated LDB3 transgenation. The patient was diagnosed as postural tachycardia syndrome (joint-hypermobility-related), Ehlers-Danlos syndrome, and relieved by fluid infusion and rehabilitation therapy.
