The relationship between insulin resistance and risk of long-term mortality in people without diabetes: a 30-year follow-up of the Daqing Diabetes Study
10.3760/cma.j.cn112138-20220206-00090
- VernacularTitle:非糖尿病人群胰岛素抵抗水平与远期全因死亡风险的相关性研究——大庆糖尿病预防30年随访研究
- Author:
Yuanchi HUI
1
;
Jinping WANG
;
Siyao HE
;
Xiaoyan XING
;
Xuan WANG
;
Fang ZHAO
;
Xin QIAN
;
Hui LI
;
Qiuhong GONG
;
Yali AN
;
Yanyan CHEN
;
Guangwei LI
Author Information
1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院内分泌中心，北京100037
- Keywords:
Insulin resistance;
Forecasting;
All-cause death
- From:
Chinese Journal of Internal Medicine
2022;61(6):659-663
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine whether insulin resistance is associated with all-cause mortality in subjects without diabetes.Methods:A total of 505 participants without diabetes, 198 with normal glucose tolerance (NGT) and 307 with impaired glucose tolerance (IGT), were recruited from the Daqing Diabetes Study. The participants were followed up for 30 years. They were stratified into three groups (tertiles) according to baseline homeostasis model assessment of insulin resistance(HOMA-IR) levels, as the HOMA-IR 0, the HOMA-IR 1 and the HOMA-IR 2 groups, to assess the predictive effect of insulin resistance on risk of all-cause mortality.Results:During the 30-year follow-up, 52, 56 and 78 participants died across the three HOMA-IR groups, respectively. The corresponding mortality per 1 000 person-years (95 %CI) were 12.12 (9.56-15.01), 13.10 (10.46-16.03) and 19.91 (16.73-23.15), respectively. Participants in the HOMA-IR 2 group had a significantly higher risk of death than those in the HOMA-IR 0 group after adjustment of age, sex and smoking status ( HR=1.97,95 %CI 1.38-2.81, P<0.001). Cox analyses showed that a one standard deviation increase in HOMA-IR was associated with a 22% increase in the mortality after adjustment of potential confounders ( HR=1.22, 95 %CI 1.08-1.39, P=0.002). Conclusions:Insulin resistance is associated with increased risk of all-cause death in Chinese people without diabetes, suggesting that improving insulin resistance could be beneficial for people without diabetic in reducing risk of long-term all-cause mortality.
