Risk factors of residual tumor in single small hepatocellular carcinoma after thermal ablation treatment
10.3760/cma.j.cn112138-20211004-00675
- VernacularTitle:热消融治疗单发小肝癌术后残留危险因素分析
- Author:
Yue HAN
1
;
Weihua ZHI
;
Shupeng FAN
;
Dong YAN
;
Fei XU
Author Information
1. 中国医学科学院肿瘤医院介入治疗科，北京100021
- Keywords:
Small hepatic carcinoma;
Percutaneous radiofrequency ablation;
Microwave ablation;
Postoperative residual
- From:
Chinese Journal of Internal Medicine
2022;61(5):543-547
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the risk factors of residual tumor after thermal ablation in patients with small hepatocellular carcinoma.Methods:This was a retrospective study recruiting 107 patients diagnosed as single hepatocellular carcinoma with maximum diameter ≤3 cm from December 2009 to August 2015 in National Cancer Center. The cohort enrolled 81 males and 26 females, including 83 patients younger than 70 years old. All patients were treated with radiofrequency ablation or microwave ablation, and evaluated by CT or MRI after 4-6 weeks compared with baseline data. Potentially related factors were analyzed such as patients′ characteristics, tumor location and adjacent, ablation pattern, hepatitis B/C infection. A multivariate logistic regression analysis was conducted for the independence of risk factors.Results:Six patients (5.6%) with residual tumor was detected in the whole population of 101 cases. Univariate analysis suggested that tumor adjacent to vascular structure, poor differentiation, AFP≥200 μg/L were the risk factors of residue disease (all P<0.05). Multivariate logistic regression suggested that pathological type of poorly differentiated tumor was the only independent risk factor ( HR=2.26,95% CI 0.25-20.50, P=0.030). Conclusions:Poorly differentiated pathology is an independent predictive factor for residual disease in small hepatocellular carcinoma after thermal ablation. Such patients should be routinely followed up after operation.
