A single-center retrospective analysis of 100 consecutive cases treated with lenalidomide/bortezomib/dexamethasone in newly diagnosed multiple myeloma
10.3760/cma.j.cn112138-20211105-00776
- VernacularTitle:来那度胺联合硼替佐米及地塞米松治疗初治多发性骨髓瘤单中心100例连续病例的回顾性分析
- Author:
Wenxiu WANG
1
;
Jingyi BI
;
Lei WEN
;
Wenbing DUAN
;
Yang LIU
;
Fengrong WANG
;
Qing HE
;
Jin LU
Author Information
1. 北京大学人民医院血液科 北京大学血液病研究所 国家血液系统疾病国家临床医学研究中心，北京100044
- Keywords:
Newly diagnosed multiple myeloma;
Lenalidomide;
Bortezomib;
Autologous stem cell transplantation
- From:
Chinese Journal of Internal Medicine
2022;61(5):531-536
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy and safety of lenalidomide combined with bortezomib and dexamethasone (RVD) in patients with newly diagnosed multiple myeloma (NDMM).Methods:A total of 100 consecutive NDMM patients treated with RVD from August 2016 to September 2020 at Peking University People′s Hospital were retrospectively analyzed, including response, drug toxicity, follow-up and survival, and subgroup analysis.Results:The median follow-up time was 19.5 (2.0-57.0) months. For patients undergoing autologous stem cell transplantation (ASCT) after RVD regimen, the objective response rate (ORR)/complete response+stringent complete response (CR+sCR)/≥very good partial response (VGPR) rates were 100%, 73.3% (33/45), 95.6% (43/45) respectively. For 54 patients not receiving transplantation, the ORR/CR+sCR/≥VGPR rates were 79.6% (43/54), 18.5% (10/54), 51.9% (28/54) respectively. As to the survival analysis, 2-year progression free survival (PFS) rates were 84.5% and 70.9% in transplant and non-transplant patients respectively ( P=0.102). Two-year overall survival (OS) rates were 100% and 80.8% in transplant and non-transplant patients respectively ( P=0.003). The common hematologic adverse events (AEs) were thrombocytopenia (33%) and neutropenia (25%). Abnormal liver function (43%) and peripheral neuropathy (24%) were recognized more as non-hematologic AEs. Conclusion:RVD as front-line regimen has high efficient response rate and acceptable safety in Chinese NDMM patients.
