Safety and efficacy of intra-arterial tirofiban infusion in patients with acute cardiogenic cerebral embolism undergoing endovascular reperfusion therapy
10.3760/cma.j.cn112138-20210414-00279
- VernacularTitle:动脉灌注替罗非班在急性心源性脑栓塞患者血管再通术中的疗效评估
- Author:
Tian LIN
1
;
Juan DU
;
Li LIU
;
Zheng WU
;
Xiangkai KONG
;
Wenbo DUAN
;
Bin DU
;
Yijiao YU
;
Wanling WEN
;
Yiling CAI
Author Information
1. 解放军战略支援部队特色医学中心神经内科，北京 100101
- Keywords:
Tirofiban;
Cardiogenic cerebral embolism;
Endovascular reperfusion therapy
- From:
Chinese Journal of Internal Medicine
2022;61(4):397-402
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the safety and efficacy of intra-arterial tirofiban infusion during endovascular reperfusion therapy in patients with acute cardiogenic cerebral embolism.Methods:Clinical data of 72 patients with acute cardiogenic cerebral embolism caused by large artery occlusion were retrospectively analyzed in Department of Neurology, Strategic Support Force Medical Center from August 2015 to August 2020.Among those, 52 patients were treated with intra-arterial tirofiban, the other 20 patients were treated with control medication. The baseline characteristics, modified thrombolysis in cerebral infarction (mTICI) score of responsible vessels, modified Rankin scale (mRS) score 90 days after operation, incidence of symptomatic intracranial hemorrhage and mortality were evaluated and compared in two groups.Results:The proportion of effective recanalization of the offending vessels (mTICI≥2b) in tirofiban group was higher than that in control group (92.3% vs. 75.0%), but the difference was not statistically significant ( P=0.104). At 90 days after operation, the rate of patients with good prognosis (mRS≤2) in tirofiban group (61.5%) was significantly higher than that in control group (35.0%) ( P<0.05). The incidence of symptomatic intracranial hemorrhage and mortality were comparable between the two groups ( P>0.05). Conclusion:Intra-arterial tirofiban infusion in patients with acute cardiogenic cerebral embolism is effective and feasible, which improves the prognosis without increasing the risk of intracranial bleeding complications.
