Clinical characteristics of patients with antisynthetase syndrome and positive anti-Ro52 antibody
10.3760/cma.j.cn112138-20210310-00202
- VernacularTitle:抗Ro52抗体阳性的抗合成酶综合征患者的临床特征分析
- Author:
Xin ZHANG
1
;
Xiangmei ZHAO
;
Qihua YANG
;
Chaofeng LIAN
;
Wei LI
;
Lu YANG
;
Jiameng LU
;
Wenjuan GUAN
;
Lijuan ZHANG
;
Shuhua CHENG
;
Hui LI
;
Shengyun LIU
Author Information
1. 郑州大学第一附属医院风湿免疫科，郑州450052
- Keywords:
Antisynthetase syndrome;
Anti-Ro52 antibody;
Lung diseases ,interstitial;
Clinical characteristics
- From:
Chinese Journal of Internal Medicine
2022;61(2):200-204
- CountryChina
- Language:Chinese
-
Abstract:
To analyze the clinical characteristics of patients with antisynthetase syndrome (ASS) and positive anti-Ro52 antibody. The clinical data of 203 ASS patients admitted to the First Affiliated Hospital of Zhengzhou University from 2017 to 2020 were analyzed retrospectively. Demographics, clinical manifestations, laboratory results, treatment and outcome were collected including data of 18 patients with rapidly progressive interstitial lung disease (RP-ILD). In total, the majority were women (148,72.9%). The average onset age was (51.9±13.3) years. There were 163 (80.3%) patients with positive anti-Ro52 antibody. The positivity in women (77.3% vs. 55.0%, P=0.004) was higher, and the median time from disease onset to diagnosis [4.5 (2.0, 24.0) months vs. 2.0 (1.0, 12.0) months, P=0.024] was longer in patients with positive anti-Ro52 antibody than those negative. Compared with negative patients, patients with positive anti-Ro52 antibody had a higher incidence of interstitial lung disease (ILD) (96.9% vs. 65.0%, P<0.001), arthritis (33.7% vs. 17.5%, P=0.046), and arthralgia (39.3% vs. 20.0%, P=0.022). Higher rate of positve antinuclear antibody (ANA) (85.3% vs. 55.0%, P<0.001), lower rate of positive anti-Jo-1 antibody (32.5% vs. 50.0%, P=0.039), lower albumin level [(34.6±5.2) g/L vs. (37.3±4.7) g/L, P=0.004] and lower lymphocyte counts [(1.4±0.8) ×10 9/L vs. (1.8±0.8) ×10 9/L, P=0.014] were more common in patients with positive anti-Ro52 antibody. The presence of anti-Ro52 antibody is associated with a particular phenotype of ASS, leading to common ILD, involvement of joints, high ANA positivity, low albumin and low lymphocyte counts.
