The characteristics and associated factors of functional limitation in patients with rheumatoid arthritis
10.3760/cma.j.cn112138-20210225-00160
- VernacularTitle:类风湿关节炎患者功能受限特征及相关因素分析
- Author:
Yaowei ZOU
1
;
Shuyan LIAN
;
Chutao CHEN
;
Tao WU
;
Xuepei ZHANG
;
Jianzi LIN
;
Jianda MA
;
Yingqian MO
;
Qian ZHANG
;
Yanhui XU
;
Yaoyao ZOU
;
Lie DAI
Author Information
1. 中山大学孙逸仙纪念医院风湿免疫科，广州 510120
- Keywords:
Arthritis,rheumatoid;
Stanford health assessment questionnaire;
Functional limitation
- From:
Chinese Journal of Internal Medicine
2022;61(2):193-199
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the characteristics of functional limitation and associated factors in patients with rheumatoid arthritis (RA).Methods:Consecutive patients with RA were recruited from August 2015 to June 2019 at Department of Rheumatology, Sun Yat-Sen Memorial Hospital. Demographic and clinical characteristics including age, gender, erythrocyte sedimentation rate (ESR), visual analogue scale (VAS) of pain, clinical disease activity index (CDAI), modified total Sharp score were collected. Physical function was assessed by the Stanford health assessment questionnaire disability index (HAQ-DI).Ordered logistic regression was used to analyze the related factors of HAQ-DI.Results:A total of 643 RA patients were finally recruited including 114 males and 529 females with mean age (49.7±12.9) years. There were 399 (62.1%) patients having different degrees of functional limitation, who were classified as mild (293, 45.6%), moderate (73, 11.4%) and severe (33, 5.1%). The prevalence of functional limitation was positively correlated with age and disease activity. The most restricted activity was walking [43.5% (280/643)], followed by gripping [36.1% (232/643)], reaching [35.5% (228/643)], daily activities [33.4% (215/643)], hygiene [33.0% (212/643)], dressing and grooming [29.7% (191/643)] and arising [29.1% (187/643)], and the last eating [18.4% (118/643)]. Multivariate ordered logistic regression analysis showed that age ( OR=1.019, 95% CI 1.004-1.035),pain VAS ( OR=1.820, 95% CI 1.616-2.050), ESR ( OR=1.009, 95% CI 1.001-1.017), CDAI ( OR=1.080, 95% CI 1.059-1.102) and modified total Sharp score ( OR=1.010, 95% CI 1.004-1.015) were associated factors of functional limitation. Conclusion:The majority RA patients have functional limitation. Age, pain and active disease are independent associated factors. Therefore, target treatment and control of pain should be emphasized in RA patients.
