C-reactive protein is associated with impaired working capacity in Chinese patients with ankylosing spondylitis in paid employment: the real-world evidence from Smart-phone SpondyloArthritis Management System
10.3760/cma.j.cn112138-20210211-00126
- VernacularTitle:C反应蛋白水平与有薪工作的强直性脊柱炎患者工作能力损失的相关性研究初探：基于脊柱关节炎智能移动管理系统的真实世界数据
- Author:
Xiaojian JI
1
;
Yiwen WANG
;
Lidong HU
;
Lei WANG
;
Xingkang LIU
;
Chuan SONG
;
Jiaxin ZHANG
;
Jian ZHU
;
Jianglin ZHANG
;
Feng HUANG
Author Information
1. 解放军总医院第一医学中心风湿免疫科，北京 100853
- Keywords:
Spondylitis,ankylosing;
C-reactive protein;
Work productivity impairment;
Mobile health
- From:
Chinese Journal of Internal Medicine
2022;61(1):99-103
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the relationship between serum C-reactive protein (CRP) levels and work impairment in patients with ankylosing spondylitis (AS) based on real-world evidence. Outpatients with confirmed AS at Chinese PLA General Hospital were recruited consecutively by Smart-phone SpondyloArthritis Management System (SpAMS) from April 2016 to April 2018. The relationship between CRP and work productivity and activity impairment questionnaire (WPAI) were evaluated. Five hundred and fifty-one outpatients with AS in paid employment were recruited. The presenteeism, overall work impairment, and activity impairment rates increased by 1.4% (1.1%, 1.8%), 1.1% (0.5%, 1.6%), and 1.7% (1.3%, 2.1%), respectively, for every 10 mg/L increase in the CRP level (all P value<0.01). However, the CRP level was not associated with absenteeism after adjusting for covariates [0.5%(-0.4%, 1.0%), P>0.05]. There is a significant association between increased serum CRP levels at baseline and the previous 7-day work impairment in patients with AS. Higher CRP levels contribute to worse presenteeism, overall work impairment, and activity impairment rates, which suggests the necessity of monitoring CRP on treatment, and also indicates that anti-inflammatory therapy may be effective for improving work productivity.
