Clinical characteristics and molecular mechanisms of hypoparathyroidism related to GATA3 gene mutation
10.3760/cma.j.cn112138-20210519-00356
- VernacularTitle:GATA3基因变异导致甲状旁腺功能减退症患者的临床特征和分子机制
- Author:
Jing YANG
1
;
Yabing WANG
;
Min NIE
;
Yan JIANG
;
Mei LI
;
Weibo XIA
;
Xiaoping XING
;
Ou WANG
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院内分泌科 协和转化医学中心 国家卫生健康委员会内分泌重点实验室，北京 100730
- Keywords:
Hypoparathyroidism;
Childhood onset;
GATA3 gene;
Deafness;
Renal dysplasia
- From:
Chinese Journal of Internal Medicine
2022;61(1):66-71
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical characteristics and molecular mechanisms of 5 cases of hypoparathyroidism caused by GATA3 gene mutation.Methods:A total of 5 childhood-onset hypoparathyroidism patients with GATA3 mutation were identified from 198 hypoparathyroidism (aged ≤18 years) from 1975 to 2021 in Peking Union Medical College Hospital. Clinical data and biochemical indices of the 5 patients were collected and analyzed retrospectively. Genetic screening was conducted by targeted next-generation sequencing (T-NGS), and bioinformatics analysis was performed to analyze the underline mechanisms.Results:The medium onset age of hypoparathyroidism of the 5 patients was 0.5 (0.1, 1.3) years old, and the time duration from onset to confirmed diagnosis of hypoparathyroidism and hypoparathyroidism- deafness-renal dysplasia syndrome was (7.0±5.2) years and (15.0±5.4) years, respectively. The clinical manifestations included carpopedal spasm accompanied by seizures (5 cases), basal ganglia calcification (5 cases), cataract (1 case), deafness (4 cases), and renal malformations or absence (2 cases). The blood calcium and blood parathormone(PTH) before treatment was (1.65±0.31) mmol/L and (4.64±2.63) ng/L, respectively. The 5 patients carried different heterozygous mutations in GATA3 gene, which caused nonsense mutations, frameshift mutations and splice site mutations, respectively. All the GATA3 gene mutations of the 5 patients are classified as pathogenic or likely pathogenic by the Clin Var database and American College of Medical Genetics and Genomics(ACMG).Conclusions:Attention should be paid to genetic diseases in patients with childhood-onset hypoparathyroidism. The possibility of hypoparathyroidism-deafness-renal dysplasia syndrome should be considered in hypoparathyroidism patients with hearing loss or renal dysplasia. GATA3 gene screening is highly recommended for the confirmation of the diagnosis.
