Ovarian steroid cell tumor, not otherwise specified: a case report and review of literature

VernacularTitle:卵巢非特异性类固醇细胞瘤病例报道一例并文献复习
Author: Yanting SHEN ¹ ; Jingjing JIANG ; Zhiqiang LU
Author Information

1. 复旦大学附属中山医院内分泌科，上海　200032
Keywords: Hyperandrogenism; Ovarian steroid cell tumor, not otherwise specified; GnRHa
From: Chinese Journal of Endocrinology and Metabolism 2022;38(5):433-436
CountryChina
Language:Chinese
Abstract: We present a case of a postmenopausal women with hyperandrogenic symptoms and virilization signs , such as hirsutism, alopecia, acne and clitoromegaly, which was pathologically confirmed to be an ovarian steroid cell tumor, not otherwise specified(NOS). The levels of testosterone, dehydroepiandrosterone sulfate and estradiol in serum were increased, while the levels of luteinizing hormone and follicle stimulating hormone were decreased. Computed tomography(CT) scan and magnetic resonance imaging(MRI) identified a solid, left ovarian tumor and detected an additional tumor of hypodensity in the left adrenal gland. ACTH stimulation test, hCG stimulation test, adrenal and ovarian vein sampling indicated that excessive androgens were derived from the ovary. After the injection of gonadotropin hormone analogues(GnRHa), testosterone levels dropped to the normal range. Laparoscopic bilateral adnexectomy was performed, and pathology indicated NOS. The purpose of this report is to improve the understanding of NOS with hyperandrogenic presentation.