Thyrotropin receptor antibody and bone turnover markers in the patients with newly-diagnosed Graves′ disease
10.3760/cma.j.cn311282-20220117-00034
- VernacularTitle:初诊Graves病患者促甲状腺激素受体抗体与骨转换标志物的相关性分析
- Author:
Yaya FAN
1
;
Mingwei SHAO
;
Jiao WANG
;
Wei ZHANG
;
Weijie WANG
;
Yuansi CHEN
;
Mengqing LIAN
;
Fangyi WEI
;
Guijun QIN
Author Information
1. 郑州大学第一附属医院内分泌与代谢病科 450052
- Keywords:
Graves′ disease;
Thyrotropin receptor antibodies;
Bone turnover markers
- From:
Chinese Journal of Endocrinology and Metabolism
2022;38(5):391-397
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between the level of thyrotropin receptor antibody(TRAb) and bone turnover markers(BTMs) in the patients with newly-diagnosed Graves′ disease(GD).Methods:The clinical data of GD patients who were newly-diagnosed in the First Affiliated Hospital of Zhengzhou University from October 2016 to June 2021 were collected, including free triiodothyronine(FT 3), free thyroxine(FT 4), thyroid stimulating hormone, thyroid related antibodies, N-terminal procollagen of type I collagen(PINP), N-terminal osteocalcin(N-MID), β-cross-linked C-telopeptide of type I(β-CTX), blood lipid and renal function, etc. Results:There were 618 GD patients with an average age of(43.7±13.2) years(male∶female=1∶1.99). The PINP and β-CTX level in male GD patients were significantly higher than those in female(all P<0.05). Spearman correlation analysis showed that PINP, N-MID and β-CTX were positively correlated with FT 3, FT 4, TRAb, serum calcium and serum phosphorus; and negatively correlated with body mass index and low density lipoprotein cholesterol(all P<0.05). Linear regression analysis showed that TRAb was positively correlated with lg-PINP, lg-N-MID and sqrt-β-CTX in the univariate model of total GD patients( β were 0.006, 0.005, and 0.006, respectively; all P<0.001); positive correlation remained after adjusting for thyroid function(all β=0.004, all P<0.001); and for multiple confounding factors(model 3 and 4, all P<0.05). Results of univariate and adjusted thyroid function models with GD in different genders were consistent with the total patients(all P<0.05). Conclusion:TRAb is a risk factor for accelerated bone turnover in GD patients which is independent of thyroid function.
