Late-onset hypogonadism in males: Guidelines and controversies

VernacularTitle:男性迟发性性腺功能减退症：指南与争议
Author: Xin HU ¹ ; Xue HAN ; Pingping XIANG ; Zhiwei HE ; Guofang CHEN ; Chao LIU
Author Information

1. 南京中医药大学附属中西医结合医院内分泌科　210028
Keywords: Late-onset hypogonadism; Diagnosis; Testosterone replacement therapy; Non-testosterone treatment
From: Chinese Journal of Endocrinology and Metabolism 2022;38(5):364-368
CountryChina
Language:Chinese
Abstract: Late-onset hypogonadism (LOH) is an age-related testosterone deficiency syndrome. With the increasing aging of society, LOH results in impaired quality of life of middle-aged and elderly men. Although domestic and international guidelines have been issued in recent years, and the management of LOH became more standardized, numerous controversies still remained in the diagnosis of LOH, the benefits of testosterone replacement therapy (TRT) and therapeutic targets. Based on comparison of different guidelines, this review focuses on age cut-off , specific signs and symptoms of LOH, diagnostic cut-off level of testosterone, the advantages and disadvantages of TRT treatment, and non-testosterone therapy.